Some food discoveries have been made by doing what I would call some alarmingly questionable stuff.

I was pretty shocked when I discovered how artificial sweeteners were generally discovered. It frequently involved a laboratory where unknown chemicals accidentally wound up in some researcher’s mouth.

Saccharin

Saccharin was produced first in 1879, by Constantin Fahlberg, a chemist working on coal tar derivatives in Ira Remsen’s laboratory at Johns Hopkins University.[21] Fahlberg noticed a sweet taste on his hand one evening, and connected this with the compound benzoic sulfimide on which he had been working that day.[22][23]

Cyclamate

Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of an antipyretic drug. He put his cigarette down on the lab bench, and when he put it back in his mouth, he discovered the sweet taste of cyclamate.[3][4]

Aspartame

Aspartame was discovered in 1965 by James M. Schlatter, a chemist working for G.D. Searle & Company. Schlatter had synthesized aspartame as an intermediate step in generating a tetrapeptide of the hormone gastrin, for use in assessing an anti-ulcer drug candidate.[54] He discovered its sweet taste when he licked his finger, which had become contaminated with aspartame, to lift up a piece of paper.[10][55]

Acesulfame potassium

Acesulfame potassium was developed after the accidental discovery of a similar compound (5,6-dimethyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide) in 1967 by Karl Clauss and Harald Jensen at Hoechst AG.[16][17] After accidentally dipping his fingers into the chemicals with which he was working, Clauss licked them to pick up a piece of paper.[18]

Sucralose

Sucralose was discovered in 1976 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King’s College London).[16] While researching novel uses of sucrose and its synthetic derivatives, Phadnis was told to “test” a chlorinated sugar compound. According to an anecdotal account, Phadnis thought Hough asked him to “taste” it, so he did and found the compound to be exceptionally sweet.[17]

Maybe we’ll find that glue pizza works.