I recently bit the bullet and bought a Kinesis Advantage360. Definitely interesting to get use to and eye wateringly expensive, but my wrist pain went away within days.

I can tell you what works for me.

I have an Uncaged Ergonomics Adjustable Under Desk Keyboard Drawer and Mouse Tray (KT2-b v2). It has a wider range of adjustment and is easy to change. I spent a week tweaking the position and it’s been perfect ever since.

My dual monitors are each attached to a Jestik Advanced Flex 1.0 Single Monitor Arm. I can position them anywhere I want at any angle and they will stay there.

My keyboard is a Kinesis Freestyle Edge RGB with Cherry MX mechanical switches. I also use their Lift Kit. The keyboard is split in half and the lift kit raises it in the center at a 30-degree angle. There is a wrist rest built into the front the of the keyboard. All of that minimizes how much my arms have to rotate without making me learn a completely different mode of typing.

I switched from a mouse to a trackball decades ago when I started to have sore wrists. My long-time driver is the Logitech MX Ergo Trackball. I put it on a stand that adds 20-degrees of tilt to get the best angle for me.

I also have a small trackpad on a small pedestal between the two halves of my keyboard. It allows me to do simple cursor movements without taking my hands of the keys.

On the rare occasions when I want a mouse I use an Anker Wireless Vertical Mouse.

It may be overkill, but I use it for eight hours a day and do not feel any discomfort.